We supply the Intermediates:
2-Amina-6-Chloro Purine (6-Chloro Guanine)
2-Amine-4,6-Dichloro Pyrimidine[56-05-3]
2,5-Diamine-4,6-Dihydroxy Pyrimidine Hcl
2-Azabicyclo [2,2,1]-Heptan-5-Ene-3-One [49805-30-3] {Vince Lactam}
Cis-4-Acetamidocyclopent-2-Ene Methyl Acetate [86252-77-9]
Dibenzoyl-L-Tartaric Acid
Cyclopropylamine
4,6-Dichloro-2,5-Diformamide Pyrimidine
(1s-Cis)-4-Amine-2-Cyclopentene-1-Methanol
CAS:188062-50-2
MF:C28H38N12O6S
MW:670.75
Pharmaco - toxicological:
This good is a new carbon ring 2'-deoxy - guanosine nucleoside drug, its high oral bioavailability and easy to infiltrate into the central nervous system. With other nucleoside reverse transcriptase inhibitors, it is a prodrug of no activity, in vivo metabolism by four steps to become an activity of triphosphate, and the adoption of the following two ways to play inhibit human immunodeficiency virus ( HIV) reverse transcriptase role: ① competitive inhibit 2'-deoxy - guanosine 3 phosphate (dGTP) (fragments of DNA synthesis) entered with nucleic acid chain. ② stop new base through the addition and effective termination of DNA chain 's synthesis .
