We supply the Intermediates:
4-Methoxy Phenyl Acetic Acid
4-Methoxy Acetophenone




CAS:125-69-9
MF:C₁₈H₂₅NO,HBr
MW:342.32


Pharmacological effects:
treatment of central nervous cough . extension of the brain by inhibiting central nervous cough control of the role. Antitussive effect approximate strength codeine. No therapeutic dose analgesic effect of no addiction. The treatment dose not inhibit respiratory center, pupil contraction, not inhibit peacekeeping hair movement, low toxicity, rapid oral absorption.

Pharmacokinetics:
After the oral absorption from the gastrointestinal tract entirely into the systemic circulation through the intestinal wall ago, the portal vein and liver metabolism (a first pass effect). The prototype drug in plasma concentration is very low. After oral administration of 60 mg, two hours or so, the concentration of drug in plasma prototype peak Cmax 34.7 ± 23.3ng/ml. Metabolism great individual differences, fast-metabolism, slow metabolic type. The main metabolites are 3 - methicillin-n - morphine, 3 - hydroxybutyrate, 17 - a morphine-n-, 3 - hydroxyl n - morphine. After 24 hours of oral drugs and the prototype of metabolites in urine excretion rate was 43 percent, 0.1 percent from faeces drained 3 - methicillin-n - morphine in the highest concentrations in plasma, the main active ingredient; in the other two metabolites the low concentration in plasma, pharmacological effects of a weak from time.

Contraindications:
Pregnancy three months and women who have mental illness history banned.