We supply the Intermediates:
2-Butyl-1,3-Diazaspiro[4,4] Non-1-En-One Hydrochloride [151257-01-1]
4'-[(2-Butyl-4-Oxo-1,3-Diazaspiro[4,4] Non-1-En-3-Yl) Methyl [1,1'-Bisphenyl]-2-Carbonitrile [138401-24-8]
2-Butyl-4-Spirocyclopentane-2-Imidazolin-5-One Hcl [138402-11-6]
2-Cyano-4'-Bromomethyl Biphenyl
1 Amino Cyclopentanacetamide
1 Carboxamido Cyclopentylamide




CAS:138402-11-6
MF:C₂₅H₂₈N₆O
MW:428.53

Indications: hypertension.

Pharmacological effects:
Angiotensin II (Angioten-sin II, Ang II) receptor antagonist, can selectively block AT1 receptors, the AT1 receptor blocker role than AT2 receptor 8500 times through selective blocking Ang II and AT1 the combination of receptors, inhibit vasoconstriction and the release of aldosterone, a pressure-relief role. At the same time can reduce pulmonary capillary wedge pressure, reduce heart before and after loading, increase cardiac output, heart failure can have a beneficial hemodynamic effects, and may delay the occurrence of left ventricular hypertrophy, prevent and reverse left ventricular hypertrophy. The goods could be reduced to the role of urine-microglobulin, a ball can be dilated renal arteries, can prevent glomerular sclerosis, hypertension with type II diabetes or renal dysfunction in patients with a protective effect.