Pharmaco - toxicological:
Organizations can increase insulin sensitivity and improve the utilization of glucose in the blood glucose lowering effect play, can significantly lower blood glucose and fasting insulin and C-peptide levels, postprandial blood glucose and insulin are significantly lower role. The glycosylated hemoglobin (HbAlc) levels decreased significantly. The drug mechanisms and the role of a specific nuclear receptor activation: peroxisome proliferator-activated receptor γ - (PPAR gamma). In humans, PPAR gamma receptor distribution in the key role of insulin target organizations such as: adipose tissue, such as muscle and liver. PPAR gamma is the role of nuclear receptor regulated insulin gene transcription reaction, and insulin response genes involved in controlling glucose produce, transfer and use. In addition, PPAR gamma response genes also regulate fatty acid metabolism. In animal models, rosiglitazone can increase the liver, muscle and fat tissue to insulin sensitivity role. Adipose tissue can be seen in the insulin-mediated glucose transporter GLUT-4 expression increased. Thiazolidinediones treatment of type 2 diabetes in patients with effective for the conditions there are certain insulin secretion capacity, such as a serious lack of insulin, has been ineffective.

Indications:
The diet control and exercise are still not satisfied with the treatment of the patients with type 2 diabetes.